Senior Scientist, Protein Sciences

Dovetail Therapeutics is a Seattle biopharmaceutical company founded in 2023 by OrbiMed, the world’s leading healthcare venture capital firm. Dovetail is committed to developing novel biotherapeutics that will meaningfully improve the lives of patients. The company has established a transformative, proprietary platform and a robust, expanding pipeline, with its lead drug candidate entering the clinic this year.

Dovetail isseekinga talented andexperiencedSenior Scientist,Protein Sciences,tojoin our growing and dynamic team. If you are passionate about developing the next generation of biotherapeutics in acreative,collaborative,and fast-paced environment where your contributions will make a real difference, this role is for you.

Key Duties and Responsibilities:

The Senior Scientist will serve as an integral member of the R&D team, executing workflows thatspanprotein science and antibody discovery. Key responsibilities include:

• Discoveryworkflow:lead and executehands-onantibody discovery tasks, includingbinding domain selection, ELISA-based screening, and DNA sequence analysis
• Proteincharacterization:develop and perform biophysical characterization of antibodies using fit-for-purpose approachesforhigh-throughput discovery needs
• Flexibleprojectexecution:providetimelysupport,adapting toprojectneedsin a dynamic environment,supporting bothdiscovery screening and protein characterization as needed
• Collaboration &communication:design and execute experimentsandeffectively communicateresults to a cross-functional team of biologists and protein engineers
• Datamanagement:Ensureaccuratedocumentation and reporting ofexperimental results, including sequence-to-function datasets
• Project coordination:Work with internal teams and external CROs to coordinate activities and ensure successful execution of deliverables

Knowledge and Skills:

The ideal candidate will be a flexibleandquick learner witha strong foundationinprotein sciences andmolecular biology.

• Broadunderstanding ofantibodydiscoveryprocess, especiallyas pertains to binding domain generation andselection
• Familiaritywith discovery screening assays (such asELISA andotherhigh-throughputassays)
• Working knowledge ofDNA sequence analysis(Benchling,Geneious, etc.)andbasicmolecularbiologytechniques
• Experience withBLI(GatororOctet)foraffinity measurement, kinetic analysis, and epitope binning
• Solidunderstanding of protein developability assays, includingapproachesto characterize andoptimizecandidates forformulation andmanufacturing
• Familiaritywithprotein purificationtechniquesusing chromatography (SEC, IEX) forlabscale production
• Strong critical thinking and the ability to thrive in a fast-paced, team-oriented environment with colleagues from diverse disciplines

Qualifications:

• Ph.D. degree in molecular biology,biochemistryor related fieldwith3+ years of industry experience,ormaster’s degree in molecular biology,biochemistryor related fieldwith5+ years of industry experienceorbachelor’s degree in molecular biology,biochemistryor related fieldwith10+ years of industry experience
• Excellentorganizational andcommunication skillswith attention to detail

We foster a culture of collaborationandinnovation, witheach team memberplayinga critical role in shaping our success. Dovetail offers a competitive total compensation and benefits package. Benefits include medical, dental and vision coverage, paid parking or transit, a 401(k) plan, and paid time off, among other components.Dovetail Therapeutics islocatedat 1616 Eastlake AvenueEast,in the vibrant South Lake Unionneighborhoodof Seattle.