Associate Director, Quantitative Pharmacology

Overview

A global biopharmaceutical company on a mission to solve unmet medical needs, Incyte follows science to find solutions for patients through the discovery, development, and commercialization of proprietary therapeutics. Incyte has established a portfolio of first‑in‑class medicines and a strong pipeline of products in Hematology, Oncology, Inflammation, and Autoimmunity.

Headquartered in Wilmington, Delaware, Incyte has operations in North America, Europe, and Asia.

Job Summary (Primary function)

We are seeking a pharmacometrician to join our Clinical and Quantitative Pharmacology organization in Translational Medicine. An Associate Director will execute the pharmacometrics strategy and model‑based analyses for clinical drug development, supporting programs and implementing model‑informed drug development (MIDD) strategies to optimize decision‑making across all phases of drug development.

Essential Functions of the Job (Key responsibilities)

• Independently conduct and report model‑based analyses including population pharmacokinetics (PK), pharmacokinetics/pharmacodynamics (PK/PD), exposure‑response modeling, model‑based meta‑analyses (MBMA), disease progression modeling, and clinical trial simulation.
• Identify opportunities where modeling and simulation can advance understanding of PK, PD, efficacy, and safety across multiple projects.
• Develop MIDD strategies across multiple programs and disease areas to optimize prospective studies, inform overall clinical development and regulatory strategies in collaboration with partners (clinical pharmacology, biostatistics, regulatory, and clinical development teams).
• Effectively communicate results, conclusions, and assumptions of pharmacometrics analyses to a variety of audiences to influence decision‑making (written and oral presentation).
• Mentor and guide peers in pharmacometrics methodologies, tools, and their application in clinical drug development.
• Stay current with scientific advancements and regulatory trends in clinical pharmacology and pharmacometrics, applying knowledge to advance drug development for the organization.
• Publish findings in peer‑reviewed journals.

Qualifications (Minimal acceptable level of education, work experience, and competency)

• Ph.D. in Pharmacometrics, Clinical Pharmacology, Applied Mathematics, Statistics, Engineering, or a related field.
• 3–5 years of related industry experience.
• Hands‑on experience with a statistical programming language and pharmacometrics analysis software, including R and NONMEM or equivalents.
• Excellent communication skills and ability to collaborate with cross‑functional teams.
• Strong time‑management skills and ability to balance execution of multiple tasks to accomplish program goals.

Disclaimer

The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.

Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.