Supervisor, Commercial Manufacturing - Night Shift

Supervisor, Commercial Manufacturing

The Supervisor, Commercial Manufacturing plays a critical role overseeing the production of Orca’s cell therapy products, ensuring adherence to strict quality standards, regulatory requirements and aseptic production techniques. This position works on shift to provide supervision and direction to Associates, Cell Therapy Production, Oncology to ensure timely and compliant manufacturing.

Shift Schedule

• Night Shift: 6:00pm to 6:30am or 6:30pm to 7:00am
• Work Week Schedule: Sunday, Monday, Tuesday + every other Wednesday or Thursday, Friday, Saturday + every other Wednesday

Responsibilities

• Supervise and lead a team of associates, cell therapy production, oncology during assigned shift operations.
• Coordinate daily manufacturing activities to meet schedule, and quality and compliance goals.
• Execute and enforce cGMP‑compliant SOPs, batch records, and safety procedures.
• Provide on‑floor training, mentorship, and performance feedback to production staff.
• Monitor and troubleshoot production activities and equipment, escalating as needed.
• Partner with QA and QC to support in‑process checks, deviation investigations, and batch record reviews.
• Maintain real‑time, accurate documentation of manufacturing processes and equipment use.
• Support continuous improvement initiatives to increase reliability and efficiency.
• Participate in CAPA and deviation investigations related to manufacturing activities.
• Remain in a stationary position 50% of the time while in a biosafety cabinet/cleanroom environment which includes wearing a PPE gown.

Qualifications

• B.S. degree required in biology or a related field.
• 2+ years of supervisory or team experience is required.
• Strong understanding of aseptic manufacturing practices and clean room operations.
• M.S. degree in biology or a related field.
• Prior experience in cell therapy or other advanced biologics.
• Familiarity with deviation investigations, CAPAs and change control processes.
• Ability to gown and work in clean rooms and biosafety safety cabinets.
• Highly detail oriented with special attention to quality.
• Strong work ethic, curiosity to learn and contribute in a fast‑paced collaborative environment.
• Strong interpersonal skills and ability to communicate effectively.
• Ability to work in a collaborative manner and independently.
• Highly tolerant and respectful of all team members.
• Visual acuity 20/20 (corrected or uncorrected) and normal color vision.
• Must meet cleanroom gowning requirements, including wearing full gowning (face coverings, gloves, hoods, goggles) for extended periods.
• Must be able to work at either Orca Bio Sacramento location based on operational needs and regularly participate in video‑based meetings.
• May be required to work scheduled overtime, weekends, or holidays based on business needs.
• Must be able to ascend/descend stairs within workspace; standing/walking is required.
• Ability to work independently and as part of a team.

Benefits

The anticipated annual salary range for this job is based on prior experience in the role/industry, education, location, internal equity, and other job‑related factors as permitted by law. Full‑time employment positions will also be eligible to receive pre‑IPO equity and an annual bonus, in addition to competitive medical, dental, and vision benefits, paid time off, a 401(k) plan, life and accidental death and disability coverage, and parental leave benefits. Other perks include subsidized daily lunches and snacks at our on‑site locations.

Equal Opportunity Employer

We’re proud to be an equal opportunity employer.