Senior Specialist, Quantitative Pharmacology and Pharmacometrics - Cardiometabolic and Ophthalmic Diseases

Job Description The Quantitative Pharmacology and Pharmacometrics (QP2) Department of our Company's Research Laboratories in West Point, PA / Rahway, NJ is seeking a curious and collaborative Senior Scientist to support our rapidly expanding cardiometabolic and ophthalmology pipelines. As a senior specialist you will be part of a cross-functional teams of experienced scientists to discover and develop novel therapeutic agents of various modalities for cardiometabolic and ophthalmic diseases. The senior specialist is a skilled quantitative scientist, with a good understanding of the strategic elements of drug discovery and development. The senior specialist should demonstrate collaborative work spirit and good communication skills. Within QP2, you have a unique opportunity to accelerate your professional career as a quantitative drug developer taking advantage of our end-to-end pipeline support in one of the world’s most research-intensive biopharmaceutical companies.

Responsibilities:

Contribute to the development of model-based strategies (translational PK/PD strategies, mechanistic model, POPPK/PD, clinical trial simulations, etc) for quantitative analyses, within and across development programs and/or departments, to inform and optimize drug discovery and all phases of drug development including, but not limited to dose selection, clinical trial design, and go/no-go decisions.

Represent QP2 on cardiometabolic and ophthalmology discovery, early clinical development and late clinical development teams, leveraging quantitative approaches to drive streamlined development of programs within our growing portfolio.

Collaborate with other functional areas, as well as with external vendors and partners, on activities related to study design, protocol development, study execution, reporting and interpretation of data.

Required:

• A Ph.D. or equivalent degree OR a PharmD or equivalent degree with at least 2 years of experience OR an MS or equivalent degree with at least 4 years of experience, where “experience” means having a record of increasing responsibility and independence in a similar role in pharmaceutical drug development, regulatory agency, or academia.
• Educational background in biopharmaceutics, pharmaceutical sciences, pharmacometrics, chemical/biomedical engineering, or a related field.
• Experience in performing population PK, PK/PD analyses using standard pharmacometrics software (e.g. NONMEM, Monolix, Phoenix, etc.).
• Good written and verbal communication, interdisciplinary collaboration, and problem scoping and planning.

Preferred:

• Knowledge in cardiometabolic and/or ophthalmology clinical drug development programs
• Skills in experimental design, mathematical problem solving, critical data analysis/interpretation, and statistics.
• Scientific understanding of biopharmaceutical and ADME properties of small molecules and/or biologics #QP2 #EligibleforERP

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities.

San Francisco Residents Only:

We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance.

Los Angeles Residents Only:

We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance.

Search Firm Representatives

Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific.

Employee Status: Regular Relocation: Domestic VISA Sponsorship: Yes Travel Requirements: 10% Flexible Work Arrangements: Hybrid Shift: Not Indicated Valid Driving License: No Hazardous Material(s): N/A

Job Posting End Date: 09/12/2026 A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date.

The salary range for this role is $129,000.00 - $203,100.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting.

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at

Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where we have codified our legacy for over a century. Our success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

The application deadline for this position is stated on this posting.