Senior Scientist, Translational Development

Position Summary

Reporting to the Director/Translational Development, this role is part of the Translational group in Cambridge, MA, managing the scientific and preclinical laboratory component of multiple immune-oncology interfacing late-stage programs (Phase 2 and beyond). Key responsibilities include leading bench-based mechanism-of-action studies, differentiation from standard-of-care molecules, combination rationale, and resistance mechanisms.

Key Responsibilities

• Perform preclinical/laboratory studies using late-stage BMS assets to support Translational Medicine annual goals.
• Deliver translational strategy data, including biomarkers, patient selection hypotheses, dose/schedule, combination strategies, resistance mechanisms, and differentiation.
• Interface with internal/external research scientists to ensure seamless information flow.
• May contribute to external preclinical collaborations.
• Maintain written reports and present results in an organized and timely manner.
• Communicate effectively, foster teamwork, and contribute to project strategy discussions.

Qualifications & Experience

• PhD with at least 2 years of relevant experience in immune-oncology, hematology and/or immunology (academic or industry).
• Strong publication record and demonstrated laboratory research track record supporting clinical development.

Technical Skills (required/preferred)

• In vitro: multi-parameter flow cytometry/cell sorting; immune effector assays (ADCC/ADCP/T-cell killing); cytokine analysis (ELISA/MSD); bulk/sc-RNA-seq.
• In vivo: end-to-end syngeneic and CDX efficacy studies; tumor immunophenotyping and transcriptomic profiling.
• Spatial technology experience (e.g., Akoya, Visium, COSMX) is a plus.
• Strong verbal/written communication and ability to develop primary manuscripts/publications.

Compensation Overview

Cambridge Crossing: $142,220 - $172,340