Senior Director, Quantitative Pharmacology and Pharmacometrics – Immuno-Oncology

Primary Responsibilities

• Lead and shape quantitative pharmacology strategy across oncology programs to inform key decisions (dose selection, trial design, go/no-go).
• Develop and implement integrated model-informed drug development (MIDD) strategies across development stages.
• Ensure modeling strategies align with regulatory expectations and business priorities.
• Lead, mentor, and develop a team of QP2 scientists (performance, hiring, retention, deliverable oversight).
• Serve as QP2 lead on assigned programs; represent QP2 in cross-functional teams/governance forums.
• Collaborate with Translational, Clinical, and Biostatistics teams; partner with preclinical teams to translate findings into clinical plans.
• Contribute to due diligence for business development/licensing.
• Develop and contribute to regulatory strategies; author/review INDs, CSRs, CTD modules, NDA/BLA submissions; represent the company with regulators/conferences.

Minimum Education

• Ph.D. in relevant discipline (≥10 years pharma industry experience) OR Master's/PharmD/equivalent (≥15 years, increasing responsibility/leadership).

Required Experience & Skills

• Background in relevant fields (biopharmaceutics/pharma sciences/pharmacimetrics/mathematics/computational biology or related) and oncology disease knowledge.
• Ability to lead interdisciplinary teams.
• Experience developing quantitative strategies impacting pipeline decisions.
• Experience independently authoring/defending marketing authorization filings (NDA/MAA).
• Inclusive, high-performance collaboration; manage ambiguity.
• Strong written/verbal communication and problem scoping/planning.

Required Skills

Clinical Development, Clinical Pharmacology, Cross-Functional Collaboration, Drug Development, Effective Written/Verbal Communication, Leadership, Oncology, Oncology Drug Development, Pharmacometrics, Regulatory Interactions/Responses, Stakeholder Relationship Management, Team Management, Translational PK/PD (PKPD).

Benefits

• Eligible for annual bonus and long-term incentive (if applicable).