Senior Director, Global Digital & Technology Systems Engineering

BeOne continues to grow at a rapid pace with challenging and exciting opportunities for experienced professionals. When considering candidates, we look for scientific and business professionals who are highly motivated, collaborative, and most importantly, share our passionate interest in fighting cancer. BeOne is a global biopharmaceutical company dedicated to the discovery and development of innovative drug therapies for the treatment of cancer. At BeOne we believe that access to life‑changing medicine sees no borders.

Role Overview

The Senior Director, Global Digital & Technology Systems Engineering operates primarily as the primary point of contact and strategic bridge to the Global Technology Solutions (Enterprise IT) function, ensuring all R&D systems align with Enterprise infrastructure, cybersecurity, identity management, and cloud platform standards. The role owns the end‑to‑end remit for systems engineering of externally developed platforms and solutions, integration engineering, and technical application lifecycles across the organization. It includes designing, configuring, and deploying HPC clusters and containerised environments, implementing observability frameworks, and architecting foundational AI and RAG pipelines.

Essential Functions

• Enterprise IT Alignment & Collaboration: Serve as the single point of contact and strategic bridge to Global Technology Solutions, ensuring R&D systems align with global infrastructure and security standards while advocating for specialised technical requirements.
• Platforms & Systems Engineering: Oversee engineering, architecture, and deployment strategies for platforms and systems, balancing on‑prem, hybrid cloud, and multi‑tenant SaaS environments. Design robust API layers, data buses, and observability frameworks to ensure seamless data interoperability and proactive system health management.
• Foundational AI Architectures & Workflow Patterns: Act as the technical SME for RAG architecture, vector storage integrations, advanced chunking strategies, semantic retrieval layers, and agentic AI system patterns that handle multi‑modal AI inputs and outputs.
• Change Management & Digital Adoption: Drive the technical change strategy for foundational infrastructure overhauls and cloud migrations in collaboration with GTS, guiding unified integration standards across development and vendor teams.
• Governance & Risk Mitigation: Collaborate with Global Technology Solutions to implement secure AI proxy layers and gateways, ensuring proprietary data and intellectual property are sandboxed and compliant with regulatory requirements.
• GRDTS Leadership: Lead, mentor, and manage a high‑performing team focused on systems engineering, fostering innovation, accountability, and professional development while ensuring regulatory compliance and operational excellence.

Key Capabilities

• Enterprise‑to‑R&D Infrastructure Bridging: Liaison to global Enterprise IT and specialist advocacy for research needs.
• External Platform Technical Assessment: Evaluate and stress‑test vendor solutions for scalability, security, and integration readiness.
• Internal & Vendor Platform Integration: Build secure, unified integration layers for internal and third‑party applications.
• Full‑Ecosystem Observability & Reliability: Implement real‑time telemetry across all platforms to maximize uptime.
• Advanced AI Architecture Scaling: Plan and scale cloud, HPC, and AI environments, including enterprise RAG and secure AI gateways.
• Technical Governance & Talent Upskilling: Drive adherence to architectural standards and reskill technical staff.

Key Competencies

• Analytical Technical Due‑Diligence: Review vendor codebases, architecture diagrams, APIs, and SLAs to assess true engineering readiness.
• Diplomatic Mindset: Navigate Enterprise IT processes and negotiate exceptions for specialised scientific stacks.
• Ecosystem‑Level System Thinking: View internal and external platforms as a cohesive, scalable system.
• Security‑First IP Stewardship: Protect Enterprise data and intellectual property across all environments.
• Transformational Change Leadership: Coach and upskill staff to adopt unified technical standards.
• Resilient Crisis Management: Lead technical operations during critical upgrades or outages.

Key Deliverables

• R&D Systems Blueprint – Technical reference documentation detailing R&D systems and external vendor platforms.
• Vendor Technical Assessment & Feasibility Reports – Formal architectural scorecards and risk assessments.
• Scalable AI/ML Architecture Patterns & Blueprints – Reusable infrastructure configurations for RAG pipelines and multi‑agent workflows.
• Ecosystem Observability & Telemetry Views – Centralised monitoring infrastructure for end‑to‑end health tracking.
• Cross‑Functional Governance & Technical Alignment Agreements – Negotiated architecture and compliance agreements co‑authored with Enterprise IT.

Qualifications

• 12+ years of professional experience in data, digital & information technology with direct oversight of systems engineering in the pharmaceutical, biotechnology, or medical device industries.
• 7+ years of proven senior leadership experience, directing multi‑skilled teams and associate‑level staff.
• Strong experience with ML/AI/genAI methods and technologies from a systems engineering perspective.
• Business relationship management acumen and a track record as a change agent in transformational initiatives.
• Experience with software lifecycle methodologies, 21CFR Part 11 compliance, and GxP computer systems validation (CSV) and ICH guidelines.
• Proficiency in Agile, Scrum, Kanban, and Lean project management disciplines.

Education & Travel

• Bachelor’s degree or higher in a relevant technical or scientific discipline.
• Some travel expected as part of assigned duties.

Benefits & Salary

• Competitive base salary range: $207,800 - $277,800 annually (location dependent).
• Comprehensive benefits package including medical, dental, vision, 401(k), FSA/HSA, life insurance, paid time off, and wellness programs.
• Eligibility for discretionary equity awards and the Employee Stock Purchase Plan.

We are proud to be an equal opportunity employer. BeOne does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, disability, national origin, veteran status, or any other basis covered by applicable law. All employment is decided on the basis of qualifications, merit, and business need.

For reasonable accommodation for individuals protected by the Rehabilitation Act of 1973, the Vietnam Era Veterans’ Readjustment Assistance Act of 1974, Title I of the Americans with Disabilities Act of 1990, or any other applicable laws, applicants who need accommodation in the application process may contact