Senior Data Scientist, Biologics Discovery

Senior Data Scientist (Biologics Discovery)

Position Summary

• Design featurization and dataset curation for antibody/protein sequence, constructs, assay, and biophysical data.
• Build and evaluate applied ML models; define evaluation frameworks to keep models trustworthy.
• Collaborate with data-infrastructure partners and In Silico Discovery (ISD) to strengthen ISD’s molecular property models.

Key Responsibilities

• Develop featurization and model-ready datasets.
• Specify features/labels/aggregation levels with data engineers; preserve raw representations.
• Curate, document, and version datasets for reproducibility and traceability.
• Partner with ISD on standardized, traceable training datasets; align on DS vs. ISD ownership.
• Frame ML problems around decision points in the DMTL cycle.
• Work with ontology and MLOps teams to ensure consistent semantics and reliable model deployment.
• Champion reproducibility, documentation, and responsible AI.

Qualifications

Required

• M.S. or Ph.D. in CS/ML/Computational Biology/Bioinformatics/Statistics or related field.
• 2+ years applied ML (model development/evaluation/dataset curation) on complex scientific/biomedical data.
• Proficiency in Python (PyTorch, scikit-learn) and SQL.
• Experience converting heterogeneous experimental data into robust features/training sets; exposure to cloud training/data infrastructure.
• Understanding of evaluation/validation, leakage, and distribution shift.
• Ability to collaborate in a matrixed R&D environment.

Preferred

• Biologics, antibody/protein sequence models, or protein language models.
• Active learning, Bayesian optimization, or sequence-based generative models.
• Familiarity with assay/biophysical data and developability endpoints.
• MLOps, experiment tracking, model monitoring.
• Ontologies/knowledge graphs for AI-ready datasets.

Benefits/Compensation (as stated)

• Base pay range: $109,000–$174,800; annual performance bonus eligibility; medical/dental/vision/life and disability/other listed insurance.
• Pension and 401(k) eligibility.
• Vacation up to 120 hours/year; sick time up to 40 hours/year; holiday/floating holidays up to 13 days/work-personal-family time up to 40 hours/year.

Locations

• Spring House, PA (strongly preferred), Titusville, NJ, or Raritan, NJ, USA; or Madrid, Spain. No remote option.