Scientist II - Oligonucleotides

Scientist II - Oligonucleotides

South San Francisco, United States | Posted on 03/20/2026

Our client, leadingleader in biotechnology and diagnostics, is looking forScientist II - Oligonucleotides basedoutofSouth San Francisco . If you are interested to discussfurther, please review the details below.

Duration: Long termcontract (Possibility of further extension)

Pay Rate: $47/hr on W2

Job Summary:

We are seeking a highly motivated and collaborativeOligonucleotide Scientist II to join the Nucleic Acid Design and Discovery team within the Protein Sciences department. This role will support the discovery and development of oligonucleotide therapeutics and contribute to advancing innovative RNA-based medicines across multiple therapeutic areas.

Key Responsibilities

• Design, develop, and execute oligonucleotide synthesis workflows using automated synthesizers
• Perform purification and characterization of oligonucleotides using techniques such as HPLC and mass spectrometry
• Troubleshoot synthesis processes and perform impurity profiling to ensure high-quality output
• Collaborate with cross-functional teams across biology, chemistry, and therapeutic areas (oncology, immunology, neuroscience)
• Conduct literature reviews and propose experimental strategies for nucleic acid chemistry
• Develop and optimize scalable synthesis methods for lead compounds
• Support preclinical studies by coordinating material production and delivery timelines
• Maintain and operate laboratory equipment including oligo synthesizers, HPLC systems, and desalting units
• Ensure accurate documentation and maintain high productivity in a fast-paced lab

Required Qualifications

• Bachelor’s or Master’s degree in Organic Chemistry, Chemistry, or a related field
• Hands‑on experience in oligonucleotide synthesis using automated synthesizers
• Strong experience in purification and characterization techniques (HPLC, Mass Spectrometry)
• Solid understanding of nucleic acid chemistry and oligonucleotide modification strategies
• Excellent problem‑solving, analytical, and troubleshooting skills
• Strong communication and teamwork abilities

Preferred Qualifications

• Experience in RNAi or oligonucleotide therapeutics discovery
• Knowledge of nucleic acid delivery systems and bioconjugation techniques
• Experience in pharmaceutical or biotechnology R&D environments
• Understanding of sequence design, mechanism of action, and therapeutic applications
• Exposure to large molecule drug discovery