Scientist II – LNP Formulation
Location: San Diego, CA (Onsite; no relocation)
Position Summary
- Seeking a motivated, detail-oriented Scientist II to join the Formulation team.
- Focus on the formulation, synthesis, and optimization of targeted and non-targeted lipid nanoparticles (LNPs) for nucleic acid delivery.
- Work closely with senior scientists to support in vitro and in vivo studies and advance non-viral delivery platforms.
Key Responsibilities
- Formulate and optimize LNPs and targeted LNPs (tLNPs) encapsulating mRNA, siRNA, or DNA.
- Execute Design of Experiments (DoE) screening campaigns to identify optimal LNP compositions and processing parameters.
- Characterize LNPs using Dynamic Light Scattering (DLS), zeta potential, and RiboGreen assays.
- Support early-stage formulation development, cryoprotection, scale-up, and stability studies.
- Collaborate with cross-functional teams to fulfill formulation requests.
- Maintain detailed laboratory records documenting formulation activities and experimental results.
- Analyze, interpret, and present experimental data to the formulation team.
- Support routine laboratory operations, including inventory tracking, supply ordering, buffer preparation, and autoclaving.
Required Qualifications
- Education and industry experience:
- Bachelor's degree in Chemistry, Biochemistry, Chemical Engineering, or a related discipline, with 5 years of biopharma industry experience; OR
- Master's degree in a related discipline, with 2 years of industry experience.
- Minimum 2 years of hands-on laboratory experience in LNP formulation and nucleic acid encapsulation.
- Experience working with mRNA, siRNA, or DNA.
- Proficiency in LNP characterization techniques, including:
- Dynamic Light Scattering (DLS)
- Zeta potential
- RiboGreen assays
- High proficiency in Microsoft Excel.
- Strong attention to detail and ability to generate reproducible experimental data.
- Excellent organizational, communication, and teamwork skills.
- Ability to work effectively in a fast-paced laboratory environment.
Preferred Qualifications
- Experience preparing targeted LNPs using:
- Monoclonal antibodies (mAbs)
- Fab fragments
- Single-chain variable fragments (scFv)
- VHH antibody fragments
- Experience with immune cell delivery.
- Familiarity with statistical and data analysis software, such as JMP or GraphPad Prism.
Technical Skills
- Lipid Nanoparticle (LNP) Formulation and Development
- Targeted Lipid Nanoparticles (tLNPs)
- Nucleic Acid Encapsulation and Delivery
- mRNA, siRNA, and DNA Delivery
- LNP Characterization and Optimization
- Dynamic Light Scattering (DLS)
- Zeta Potential Analysis
- RiboGreen Assays and Encapsulation Efficiency
- Design of Experiments (DoE)
- Experimental Design and Data Analysis
- Formulation Stability Studies
- Cryoprotection and Scale-Up
- In Vitro and In Vivo Formulation Support
- Microsoft Excel
- JMP / GraphPad Prism
- Laboratory Documentation and Recordkeeping
- Buffer Preparation and Inventory Management
- Cross-Functional Collaboration
Scientist II - LNP Formulation in San Diego at eTeam
This position is listed as full time and onsite. It was posted 5 days ago.