Scientist, Computational Chemist & MLOps Engineer

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes.

RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics.

Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI.  Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. The PositionWe are seeking a highly motivated computational scientist to join our research organization and contribute to machine learning–driven drug discovery efforts. This role will focus on data engineering, statistical modeling, bioinformatics, and scientific software development supporting internal therapeutic design programs. The ideal candidate combines strong quantitative reasoning with practical software engineering skills and is comfortable operating independently in a Linux-based research computing environment.This position may be filled at the Scientist I - III level depending on experience and qualifications.ResponsibilitiesDevelop and apply statistical and machine learning models to experimental datasetsDesign, maintain, and optimize scientific databases and data processing pipelinesBuild reproducible computational workflows for bioinformatics and drug discovery applicationsAnalyze high-dimensional biological datasets and communicate findings to multidisciplinary teamsContribute production-quality Python code and maintain version-controlled scientific softwareOperate effectively in Linux/HPC environments, including remote systems and cloud-based infrastructureWrite clear, maintainable, and testable scientific codeDebug complex computational and data issues independentlyOperate effectively in terminal/Linux-native workflowsApply statistically rigorous thinking to experimental interpretationMaintain reproducibility and software engineering discipline in research environmentsPartner with scientists across biology, chemistry, bioinformatics, and computational research groupsSupport development of internal computational platforms and modeling infrastructureDocument workflows, analyses, and software according to reproducible research standardsMentor junior team members and contribute to technical best practices (Scientist II/III)RequirementsScientist IBachelor’s or Master’s degree in Bioinformatics, Biostatistics, Computational Biology, Computer Science, Data Science, Applied Mathematics, or related fieldStrong programming experience in PythonExperience working in Linux command-line environmentsFoundational understanding of statistics and machine learning methodsExperience handling structured and unstructured biological datasetsFamiliarity with source control tools such as Git Scientist III (In addition to the above)Advanced degree (PhD preferred) or equivalent industry experienceDemonstrated history of leading computational projects independentlyStrong background in applied statistics, predictive modeling, and experimental data interpretationExperience mentoring scientists or leading technical initiativesAbility to translate ambiguous scientific problems into robust computational solutions PreferredExperience with predictive modeling and/or deep learning methodsFamiliarity with modern ML tooling and model evaluation methodologiesExperience in therapeutic design, RNA biology, genomics, or laboratory experienceExperience with bioinformatics workflows and sequence-based analysisExperience working with large-scale biological or omics datasetsExperience with distributed computing systemsExperience operating in collaborative software development environmentsWisconsin pay range $100,000—$125,000 USDArrowhead provides competitive salaries and an excellent benefit package.   Candidates must have current, valid authorization to work in the country where this role is located.California Applicant Privacy Policy