Research Associate

Title: Research Associate, RNAi Chemical Development

DURATION: 1+ year with the potential to extend (up to 2-year max)

LOCATION: Boulder, CO – ONSITE

SCHEDULE: 8am-5pm (some flexibility)

MUST HAVES:

Science/engineering degree (AS, BS, BA degree)

Excitement for the role and willing personality

Team mentality and strong communication skills

PURPOSE

This role supports delivery of high-quality oligonucleotide starting materials to innovation and process development teams, enabling ligation-based RNAi manufacturing development and platform expansion.

The position is responsible for maintaining a reliable supply system to support fast-paced program advancement.

RELATIONSHIPS

• Collaborates with RNAi Chemical Development, Innovation, and Scale-Up teams.
• Interfaces with API development and oligonucleotide production stakeholders.
• Individual contributor within a cross-functional environment.

ESSENTIAL FUNCTIONS

• Support preparation and delivery of oligonucleotide starting materials.
• Execute laboratory procedures related to oligonucleotide synthesis, processing, and purification.
• Operate and maintain workflows ensuring reliable material supply.
• Support ligation development through timely substrate preparation.
• Maintain equipment and document workflows and materials.
• Drive continuous improvement in efficiency and scalability.

QUALIFICATIONS

Education: Bachelor’s or Master’s in chemistry, biochemistry, or related field.

Experience: 0–3+ years of relevant lab experience.

Technical Skills:

• Familiarity with standard laboratory techniques.
• Experience with HPLC or LC-MS is a plus.
• Familiarity with automated oligonucleotide synthesizers (e.g., Mermade systems) is preferred.
• Experience with ion-exchange purification methods for oligonucleotides is preferred.
• Basic understanding of RNAi or oligonucleotide chemistry preferred.