Principal Scientist I/II – Hematopoietic Stem Cell & RBC Biology

Major accountabilities:

• Apply expertise in sickle cell disease, hematopoietic stem cell biology, and RBC pathophysiology to support Global Health research initiatives.
• Design, execute, and interpret high-quality biological experiments that inform target discovery, validation, and early drug discovery.
• Translate biological insights into actionable hypotheses and therapeutic concepts in collaboration with multidisciplinary project teams.
• Take on increasing scientific leadership responsibilities, including mentoring junior scientists and contributing to team development (with future people-management growth opportunities).
• Foster a collaborative, inclusive, and high-performance culture aligned with Novartis Values & Behaviors.
• Contribute to project discussions, data reviews, and decision making in a matrixed Biomedical Research environment.
• Maintain awareness of external scientific advances and contribute to publications or scientific exchanges as appropriate.
• Ensure all work is conducted to the highest standards of scientific rigor, data integrity, safety, and compliance.

Minimum Requirements:

• PhD in Molecular Biology, Cell Biology, Immunology, Biochemistry, Microbiology, Virology, Biophysics, Pharmacology, or related biological science discipline.
• Deep expertise in sickle cell disease, red blood cell physiology, and/or hematopoietic stem cell biology, with strong understanding of hemoglobinopathies.
• Strong data interpretation, critical thinking, and scientific communication skills.
• Proven ability to independently design experiments, analyze data, and advance scientific questions (publications/patents/presentations/drug discovery contributions).
• Behaviors aligned with Inspired, Curious, Unbossed, and Integrity.

Preferred Qualifications:

• Early-career scientists (recent PhD/postdoc) transitioning into/expanding drug discovery experience.
• Experience in multidisciplinary and matrixed environments.
• Experience contributing to therapeutic programs from target identification/validation through lead generation and/or early development.
• Assay development expertise (in vitro, ex vivo, and/or in vivo systems).
• Prior high-dimensional flow cytometry experience (panel design, execution, data analysis) preferred.

Compensation/Benefits (if applicable):

• Expected salary range: $108,500–$208,500 USD annually; performance-based cash incentive; potential eligibility for annual equity awards.
• US-based eligible employees: comprehensive benefits package and time off.