Principal Scientist, Cell Line Genome Engineering

Responsibilities:

• Design, engineer, and validate physiologically and/or disease-relevant cellular systems to enable initiation and progression of drug discovery programs.
• Develop advanced engineered cellular models to support drug discovery within Lead Discovery and Optimization.
• Guide project teams in selecting appropriate cellular models at project outset to ensure biological alignment and maximize translational impact.
• Collaborate with internal teams and external academic/industry partners; integrate insights into innovative, research-driven solutions.

Qualifications:

• Master's degree in molecular biology, cell biology, bioengineering (or related) and 6+ years academic/industry experience OR PhD and 4+ years academic/industry experience.

Required/Preferred Skills (from posting):

• Deep genome biology knowledge (gene regulation and impact on cellular function) applied to engineered cellular systems.
• Hands‑on CRISPR genome engineering (e.g., Cas9/Cas12a/dCas9; base/prime editing) and gene delivery methods (lentiviral, AAV, electroporation, transposon) to build/scale/optimize cellular models.
• Expertise engineering diverse cellular systems (established cell lines, primary cells, physiologically relevant models) and model selection for discovery questions.
• High‑content imaging and cell painting experience.
• Genomic sequence analysis/bioinformatics including short/long‑read sequencing for experimental design, clonal characterization, and validation.
• Experience integrating AI‑guided/AI‑enabled cell line engineering (computational models to design/interpret perturbations and phenotypes).
• Strong analytical/data interpretation skills; ability to influence scientific/strategic decisions.
• Lead/influence cross‑functional teams in a matrixed environment; excellent communication.

Benefits (explicitly listed):

• Health coverage
• wellbeing support programs
• 401(k)
• disability/life/insurance
• legal support
• paid time off (including flexible time off/annual vacation per eligibility)
• potential additional time off (e.g., sick time, volunteer days, leaves, Global Shutdown)