Principal Scientist, Cardiovascular Translational Biomarker

Position Summary

Translational scientist with cardiovascular biology background to identify and discover biomarkers supporting progression of late-discovery programs to early phase clinical trials. Collaborate with development; may serve as discovery-to-development liaison. Establish pharmacodynamic endpoints consistent with mechanism of action using in vivo/functional-structural analyses and ex vivo/in vitro biochemical or molecular assays (including novel assay development). Test translational hypotheses using human samples or human-relevant systems; primarily on-site, lab-based.

Position Responsibilities

• Define pharmacodynamic biomarkers of response and disease progression; explain clinical translation.
• Design experiments; perform/interpret lab work (cell culture, immunoassays ELISA/MSD, IHC, protein signaling, qPCR).
• Make in-life experimental modifications as needed.
• Lead studies to completion; analyze samples internally or direct CRO studies.
• Critically evaluate programs; present findings/recommendations.
• Document and present data in a timely manner; collaborate cross-functionally.
• Train and guide team members.
• Author reports/abstracts/publications.

Basic Qualifications

• Bachelor's: 8+ years (academic/industry) OR Master's: 6+ years OR Ph.D.: 4+ years.

Preferred Qualifications/Skills

• Strong cardiovascular physiology and preclinical/clinical methodologies; imaging biomarkers (e.g., ultrasound-echocardiography, MRI, PET).
• Apply 3Rs; species-specific animal research considerations.
• Rodent handling experience.
• iPSC-CM/primary cardiac cell/engineered heart tissue expertise.
• Excellent, accurate/reproducible lab skills; manage external collaborators; self-motivated, detail-oriented, collaborative.

Benefits (explicit)

• Health coverage (medical/pharmacy/dental/vision); wellbeing support; 401(k); disability and life insurance.
• Paid time off includes flexible/unlimited time off for US exempt employees and other vacation/holiday options depending on location.