Principal Oligo Data Scientist

The oligotherapy principal data scientist role is embedded in and directly supports the Oligo Sciences team whose broad remit is the design, characterization, and early development of oligonucleotide therapies. Oligo data scientists will serve a dual purpose of co‑developing a data capture & analysis platform with oligo sciences experts and translating their needs broadly across GSK to build methods/models/capabilities that fulfil them.

Key Responsibilities

• Co-design and implement a target tractability system for oligo‑guided therapeutic mechanisms such as RNA degradation/interference, and up/down modulation of alternative splicing, poly‑adenylation, A>I editing, etc.
• Co‑develop a target/complex engagement model that combines target sequence, secondary+ tertiary structure, and oligo chemistry to drive binding assay designs for both high‑throughput screening and low‑latency optimization.
• Collaborate effectively with renowned GSK experts in genetics, genomics, computational bio & chem, structural biology and medicinal chemistry, artificial intelligence / machine learning, and digital technologies to build the datasets, tools, models, and infrastructure necessary for oligo design & development.

Basic Qualifications

• MS degree in computational life science (bio/med/chem/stats/informatics) with at least 1 published work and at least 5 years of industry experience
• Over 1 year experience with genomic data infrastructure for either public or private collections (e.g. ENCODE, TCGA, DepMap, GTEx, cellXgene, UK biobank)
• Over 1 year experience with Cheminformatic or structural modelling of drug‑target binding for small or large molecules validated by real qSAR assays

Preferred Qualifications

• PhD degree in computational life science (bio/med/chem/stats/informatics) with at least 1 published work
• Demonstrated cross‑functional communication, matrixed collaboration, both team and thought leadership
• Performed target identification or tractability/prioritization for RNA‑modulating approaches or RNA‑targeted modalities

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at (US Toll Free) or (outside US).

GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit GSK’s Transparency Reporting For the Record site.