Oligonucleotide Scientist II

Job Title: Scientist II - Oligonucleotide Discovery

Workplace Type: On-site

Employment Type: Contract on W2

Contract Duration: 12 Months (Possible Extension)

Job Description

We are seeking a Scientist II to support an innovative research team focused on oligonucleotide therapeutics discovery . This role offers the opportunity to contribute to cutting-edge RNA-based drug discovery programs in a highly collaborative research environment.

The successful candidate will work alongside multidisciplinary scientists supporting therapeutic programs across neuroscience, oncology, and immunology while driving nucleic acid chemistry and oligonucleotide synthesis activities.

Responsibilities

• Perform automated oligonucleotide synthesis using oligo synthesizers.


• Purify and characterize oligonucleotides using HPLC and Mass Spectrometry.


• Troubleshoot synthesis processes and impurity profiling.


• Develop and optimize nucleic acid chemistry workflows.


• Support lead molecule scale-up synthesis for preclinical studies.


• Collaborate with cross-functional biology and chemistry teams.


• Maintain laboratory instrumentation including oligo synthesizers, HPLC systems, and desalting equipment.


• Analyze experimental data and support therapeutic candidate progression.


• Review scientific literature and propose innovative chemistry strategies.


• Maintain accurate laboratory documentation while meeting project timelines.

Required Qualifications

• BS or MS in Organic Chemistry or related scientific discipline.


• Hands-on experience with automated oligonucleotide synthesis.


• Experience with HPLC purification and Mass Spectrometry characterization.


• Knowledge of nucleic acid chemistry and oligonucleotide therapeutics.


• Strong analytical and troubleshooting skills.


• Excellent written and verbal communication skills.


• Ability to work independently and collaboratively in a fast-paced research environment.

Preferred Qualifications

• Industry experience in pharmaceutical or biotechnology R&D.


• Experience with RNAi therapeutics.


• Knowledge of siRNA, ASO, or other nucleic acid therapeutic modalities.


• Experience with oligonucleotide delivery technologies.


• Bio-conjugation or large molecule drug discovery experience.

Interview Process

• Local candidates attend onsite.


• Non-local candidates may interview virtually.