Mixed Modality (Oligonucleotide) Scientist

Role

Principal Scientist specializing in oligonucleotide process transfer and scale-up within Lilly's new Medicine Foundry, focusing on delivering clinical supply readiness for early-phase trials.

Responsibilities

• oversee process transfer from development to manufacturing, troubleshoot production issues, evaluate and scale-up synthesis/purification methods, author technical documentation, lead process improvements, and support investigations and deviations; mentor junior staff.

Requirements

• B.S. or M.S. in Chemistry, Biochemistry, or related;
• 7+ years (M.S.) or 10+ years (B.S.) experience in oligonucleotide process development or manufacturing;
• expertise in oligo synthesis, chromatography, TFF, lyophilization;
• strong data analysis and scientific troubleshooting skills;
• experience working with GMP regulated environments.

Preferred

• knowledge of upstream/downstream oligonucleotide processing, advanced analytical techniques (HPLC/UPLC, LC-MS), and process chemistry concepts;
• prior supervisory experience.

High-Value

• focus on synthetic molecules and biologics, early-stage clinical manufacturing, process transfer, and cGMP compliance.

Location

initial at Indianapolis, permanent at Lebanon, Indiana; <5% travel; work in manufacturing/lab settings.