Executive Director, Biotherapeutics DMPK

General Summary

Executive Director, Biotherapeutics DMPK-Bioanalysis (DMPK-BA) to guide DMPK-BA strategy across Boston and Seattle teams (Vertex Biologics and Cell & Genetic Therapies) as part of the Global DMPK leadership team. Integrate PK, bioanalysis, ADME, and translational PKPD insights into cross-functional program decisions and development plans.

Key Responsibilities

• Develop vision, strategy, and capabilities for Biotherapeutics DMPK-BA teams aligned with Global DMPK-BA and Vertex R&D.
• Develop and execute DMPK-BA scientific strategies from discovery through clinical development (preclinical PK, ADME, bioanalytical and immunogenicity assays; translational PKPD for dose selection/clinical projections).
• Communicate DMPK-BA findings, implications, and recommendations to teams, senior leadership, and governance bodies.
• Build cross-functional partnerships with Biology, Preclinical Safety, Clinical Pharmacology, CMC, and other R&D disciplines.
• Implement innovative technologies/approaches to improve impact and/or efficiency.
• Provide scientific and managerial leadership for prioritization and delivery of key projects.
• Ensure scientific excellence and regulatory compliance for DMPK documents/reports (investigator brochures, INDs/equivalents, marketing applications).
• Hire, develop, manage, and retain talent.
• Drive internal/external sourcing; contribute to resource allocation, staffing, expenses, capital budget, and implementation plans.
• Participate in review of business development opportunities.

Qualifications

• PhD in Pharmacokinetics, Biochemistry, Biology, or related field; 15+ years industry experience at management level.
• Track record managing DMPK-BA teams across more than one therapeutic area; extensive experience with biotherapeutic modalities (protein, antibody/nucleic acid therapeutics, cell and gene therapies).
• Deep expertise in PK, ADME, bioanalysis, immunogenicity, biotransformation, and translational PKPD modeling for biologics.
• Excellent communication; ability to build cross-site/function collaborations.
• Ability to evaluate and implement new science/technology.
• Experience preparing regulatory submissions and interacting with health authorities.
• Strong management/leadership with mentoring of emerging talent.

Pay Range: $268,000 - $402,000 Annual bonus and annual equity awards.