Job title: Distinguished Scientist, Transgenic Model and Technology
Location: Cambridge, MA
About The Job
The Translational In Vivo Models (TIM) department within Sanofi's R&D is seeking an exceptional Distinguished Scientist to lead our Transgenic Model & Technology (TMT) function globally. This strategic leadership role will drive innovation in genome engineering and genetically modified model development to accelerate drug discovery across all therapeutic divisions.
As the G lobal Head of Transgenic Biology , you will ensure our organization remains at the forefront of technical developments in genome engineering, enabling breakthrough discoveries in immunology, immuno-inflammation, rare diseases, neuroscience, and oncology. You will serve as a key scientific advisor and strategic thinker, shaping the direction of in vivo and preclinical research programs while championing the integration of emerging technologies including AI and digital platforms into transgenic science.
This role is based in Cambridge, MA and is primarily office/lab-based with some scope for flexible remote working.
Key Responsibilities
Scientific Leadership & Innovation
Lead and advance state-of-the-art genome engineering techniques and mouse genetics applications for in vivo model development supporting discovery and developmental research
Apply personal expertise in transgenesis and CRISPR technology to devise and execute sophisticated experimental strategies for target validation, proof-of-concept, and efficacy studies
Identify, evaluate, and implement new technologies and innovations in transgenesis, CRISPR/Cas systems, and emerging genome engineering platforms
Serve as a strategic thinker and scientific advisor to research projects across therapeutic areas, providing expert guidance on in vivo and preclinical study design
Champion the integration of AI and digital technologies to enhance model design, data analysis, and predictive capabilities in transgenic research
Cover a broad scientific scope including immunology and immuno-inflammation, rare diseases, neuroscience, molecular and immune-oncology, and all areas of cell and molecular biology pertaining to immunology and immune-oncology
Strategic Planning & Cross-Functional Leadership
Demonstrate strategic thinking and orientation in aligning transgenic capabilities with organizational research priorities and long-term scientific goals
Lead and coordinate transversal teams and projects across multiple therapeutic divisions, sites, and external partners
Collaborate closely with the Head of Transgenic Division, drug discovery program leaders, cluster heads, and department heads to provide strategic scientific advice
Drive budget planning, forecasting, and financial management to optimize resource allocation and operational efficiency
Operational Excellence & Partnership Management
Establish and maintain comprehensive project management frameworks ensuring full-service delivery from model design through study-ready animal production
Build and manage strategic relationships with model providers, CROs, and academic partners for development and delivery of genetically modified models
Negotiate and oversee license agreements and partnership contracts for model acquisition and technology access
Implement quality standards and continuous improvement initiatives to maintain operational excellence
People Leadership & Development
Supervise, mentor, and develop staff members to build a high-performing team at the forefront of transgenic science
Participate in talent management decisions including hiring, promotions, performance evaluations, and organizational development
Foster a culture of scientific excellence, innovation, collaboration, and continuous learning
Minimum Education And Experience Required
Ph.D. in Molecular Biology, Genetics, Developmental Biology, or a related discipline
Extensive post-doctoral or industry experience in mouse molecular genetics and transgenic animal model development
Demonstrated track record of scientific leadership in an academic or pharmaceutical/biotech research environment
Minimum of 5 years of demonstrated, hands-on experience performing this role.
Additional Qualifications
Technical Expertise
Deep expertise in developing transgenic animal models, including engineering diverse genetic alleles using CRISPR/Cas9, Cas12, base editors, prime editors , and other advanced genome engineering systems
Comprehensive knowledge of both theoretical principles and practical methodologies required to lead a state-of-the-art transgenic facility
Strong foundation in molecular biology, mouse genetics, embryology, and reproductive technologies
Experience across multiple therapeutic areas (immunology, oncology, rare diseases, neuroscience preferred)
Leadership & Strategic Capabilities
Proven strategic thinking and orientation with ability to align scientific capabilities with business objectives
Demonstrated success leading transversal teams and managing complex, multi-stakeholder projects across sites and functions
Established track record as a scientific thinker and advisor to in vivo and preclinical research programs
Experience identifying, evaluating, and implementing new technologies and innovations in a research setting
Familiarity with and application of AI and digital technologies in biological research, model design, and data analysis
Professional Skills
Exceptional project management skills with ability to oversee multiple concurrent initiatives
Strong contract negotiation and vendor management capabilities
Excellent budget planning, financial management, and resource allocation skills
Outstanding interpersonal and communication skills (written and verbal) for effective collaboration across diverse, global stakeholders
Proven ability to work in matrix organizations and influence without direct authority
Personal Attributes
Self-motivated with demonstrated ability to lead and thrive in collaborative team environments
Comfortable managing competing priorities and adapting to dynamic research needs
Commitment to scientific excellence, integrity, and ethical research practices
Passion for mentoring and developing scientific talent
Candidates must be willing to travel as part of this position.
What We Offer
Opportunity to shape the future of transgenic technology at a global biopharmaceutical leader
Access to cutting-edge technologies and resources across a world-class R&D organization
Collaborative, innovative research environment spanning multiple therapeutic areas
Competitive Compensation And Comprehensive Benefits Package
Professional development and career growth opportunities
Flexible work arrangements supporting work-life balance
Why Choose Us?
- Bring the miracles of science to life alongside a supportive, future-focused team.
- Discover endless opportunities to grow your talent and drive your career, whether its through a promotion or lateral move, at home or internationally.
- Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
- Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks gender-neutral parental leave.
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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.
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