Responsibilities
- Lead evaluation of therapeutic targets, including structural, sequence, and domain architecture analysis.
- Integrate internal and external data (literature, databases, structural repositories).
- Define antigen and engineered-cell design strategies to support antibody discovery: construct design and domain selection, epitope exposure and conformational state optimization, strategies for difficult targets (e.g., multi-pass membrane proteins) including nanodisc technology and nucleic acid immunogen design.
- Apply computational and structural biology approaches to protein design: homology modeling, structural analysis, and rational mutagenesis.
- Integrate emerging AI/ML-based protein design tools.
- Engineer proteins to improve stability and expression, functional relevance for discovery assays and immunization.
Requirements
- A minimum of a Ph.D. in Biochemistry, Structural Biology, Protein Engineering, or a related discipline.
- A minimum of 10 years of experience in biologics discovery or protein sciences.
- Demonstrated leadership experience within the pharmaceutical or biotech industry.
- Strong knowledge in: antigen design and generation for antibody discovery; structural biology and protein sequence analysis; biologics discovery workflows from target to lead identification.
- Experience or domain knowledge in Oncology, Immunology, and/or Neuroscience is preferred.
- People management experience is preferred.
- Excellent verbal and written communication skills.
- Strategic with a strong scientific mindset.
- Ability to operate effectively within a highly coordinated, fast-paced matrix environment.
Core Competencies
Expertise in protein engineering and structural biology, with a strong focus on antigen design and biologics discovery workflows. Proven leadership in the pharmaceutical or biotech industry, complemented by excellent communication skills and the ability to thrive in fast-paced environments.
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