Director Precision Medicine

The Precision Medicine group at Regeneron is responsible for designing, implementing, executing, analyzing and interpreting the overarching clinical biomarker strategies for therapeutic candidates during clinical development. We are seeking to hire a hands‑on Precision Medicine Strategy Lead (PMSL) at the director level, with backgrounds in one or more therapeutic areas within the group. The role will independently oversee the development and execution of biomarker strategies across one (or more) therapeutic areas, with a preference in obesity / metabolism pharmaceutical development. The following therapeutic areas are in scope: Neurodegenerative Disorders, Cardiovascular Disease, Muscle and Metabolism Disorders, and/or Rare Genetic Diseases. In this highly matrixed role, the PMSL will design, develop, communicate at senior levels and operationally implement clinical biomarker strategies to support key programs in early and late stage drug development. Clinical technologies applied include biomarker assays, pharmacogenetic assessments, and other clinical and physiological testing devices.

A Typical Day May Include

• Enhancing our understanding of indications at a cellular and molecular level.
• Conducting novel biomarker discovery and qualifying new biomarkers/approaches to expedite proof‑of‑concept for new drug candidates.
• Optimizing label claims for later stage candidates, enabling personalized medicine principles to be applied, where appropriate, in full development.
• Focusing on therapeutic areas outside of oncology, with a broad understanding of disparate biomarker technologies and deep experience in biomarker assay development and validation in clinical drug development.
• Conducting in‑depth literature and technology reviews pertinent to assigned clinical development programs, identifying and pulling in experts in multiple disease areas, and navigating and supporting the logistical and regulatory factors pertaining to clinical technologies.

This role may be for you if you have experience with the following

• TA‑level lead for implementation of strategic vision for clinical biomarkers in one or more therapeutic areas across multiple programs, enabling advances in target identification, indication selection, early indication of biological activity, and patient stratification/selection.
• Serving as an individual contributor and senior‑level representative of Precision Medicine on development teams, delivering biomarker strategies from initial concept to execution, data delivery, and results interpretation.
• Collaborating with Discovery Research and product development teams to facilitate appropriate incorporation of Precision Medicine and clinical biomarker strategies for molecules in discovery phases.
• Representing Regeneron and working with colleagues from allied companies to develop and implement strategies for partnered alliances.
• Collaborating with clinical operations teams to implement specific biomarker and exploratory sample collection and analyses in all relevant clinical studies in selected programs.
• Designing, overseeing, and managing internal and external research collaborations in areas of clinical technologies and translational research.
• Ensuring complex clinical assays used in programs in the TFA portfolio of clinical development are fit‑for‑purpose, whether developed and validated internally or externally.
• Collaborating with internal Regeneron laboratories (e.g. Discovery Research, Molecular Profiling, Regeneron Genetics Center, DNA core, BioAnalysis, etc.) to develop plans for validation and application of research assays.
• Ensuring timely delivery of results across selected programs, consistent with program team and senior management expectations to increase the potential impact of Precision Medicine deliverables on Global Development programs.
• Contributing to and ensuring the quality of Precision Medicine technical reports, study memos and clinical study reports, data reviews and interpretations, scientific publications, and recommendations to development teams and management.

Qualifications

To be considered for this role you must have a PhD and 10+ years of experience driving, managing, executing, and delivering results for complex multi‑functional projects. You must have excellent communication and presentation skills, high emotional intelligence, organizational skills, and effective team skills. A strong track record in mentorship and development of direct reports is required.

Salary Range (annually): $205,000.00 – $341,600.00

Regeneron is an equal‑opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, belief, sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, Regeneron will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.