Role
Senior scientific leader as Director of Bioconjugation, focusing on antibody-drug conjugates (ADCs) and antibody-RNA conjugates (ARCs/AOCs).
Objectives
Defining bioconjugation strategies, leading a team of scientists, partnering across disciplines to advance conjugate therapeutics from target selection through candidate nomination and transition to development.
Responsibilities
Setting the bioconjugation platform strategy; overseeing chemistry, linker-payload design, and conjugation technology; managing external collaborations.
Requirements
PhD in chemistry, biochemistry, or related, with 8+ years in industry or academia, including at least 6 years in leadership roles. Deep expertise in bioconjugation chemistry—cysteine/lysine conjugation, site-specific and enzymatic methods, click chemistry—and experience with cytotoxic payloads, oligonucleotide conjugates, and degrader platforms. Proven track record in advancing discovery programs to clinical candidates, with strong analytical skills (RP-HPLC, SEC, LC-MS).
Preferred qualifications
Leadership in discovery project teams, oligonucleotide therapeutics, glycan-mediated platforms, and CMC/tech transfer experience supporting IND-enabling packages.
High-value specifics
Antibody conjugates, payload diversity (small molecules, oligonucleotides, degraders), therapeutic areas, and portfolio strategy.
Collaboration
Cross-functional with Discovery Chemistry, Biology, DMPK, Toxicology, and external partners.
Work setup
Location not explicitly specified, likely hybrid or onsite given the role's strategic leadership and collaboration scope.
#J-18808-LjbffrDirector, Bioconjugation in cambridge at Unknown Company
This position is listed as full time and hybrid.